inclusion criteria: - signed informed consent - at least 18 years old - subjects must be hospitalized and have the following: - proven or high suspicion of sars-cov-2 infection and, - requiring oxygen supplementation defined as: - spo2 ≤ 92% regardless of supplemental oxygen (ie on room air or on oxygen), or - spo2 ≥ 92% on supplemental o2 and in the opinion of the investigator it is not safe to decrease or remove the supplemental oxygen - require supplemental oxygen of no more than 10 l/minute, and - radiologic suspected or proven covid-19 pneumonitis (chest x-ray or ct scan) - female subjects must have a negative pregnancy test - willing and able to comply with the treatment schedule and study procedures

inclusion criteria: - signed informed consent - at least 18 years old - subjects must be hospitalized and have the following: - proven or high suspicion of sars-cov-2 infection and, - requiring oxygen supplementation defined as: - spo2 ≤ 92% regardless of supplemental oxygen (ie on room air or on oxygen), or - spo2 ≥ 92% on supplemental o2 and in the opinion of the investigator it is not safe to decrease or remove the supplemental oxygen - require supplemental oxygen of no more than 10 l/minute, and - radiologic suspected or proven covid-19 pneumonitis (chest x-ray or ct scan) - female subjects must have a negative pregnancy test - willing and able to comply with the treatment schedule and study procedures