inclusion criteria: - adult intensive care patients (aged 18 years or above) - confirmed covid-19 infection - need for mechanical ventilation (< 72 hours at time of screening) - soluble thrombomodulin (stm) ≥ 4 ng/ml

inclusion criteria: - adult intensive care patients (aged 18 years or above) - confirmed covid-19 infection - need for mechanical ventilation (< 72 hours at time of screening) - soluble thrombomodulin (stm) ≥ 4 ng/ml