inclusion criteria: - age = or > than 18 years; . - laboratory-proven covid-19 infection by rt-pcr in any clinical sample . time since symptom onset less than 10 days at the time of screening; - . presence of covid-19 pneumonia, with a typical, indeterminate or atypical compatible image in a chest tomography exam (see definition below) - - presence of one of the following criteria: - need for> 3l of o2 in the catheter / mask or> 25% in the venturi mask to maintain o2 saturation> 92% b presence of respiratory distress syndrome with pao2 / fio2 <300mmhg if intubated, within 48 hours of orotracheal intubation - absence of a history of serious adverse reactions to transfusion, for example, anaphylaxis; - .participation approval by the research clinician

inclusion criteria: - age = or > than 18 years; . - laboratory-proven covid-19 infection by rt-pcr in any clinical sample . time since symptom onset less than 10 days at the time of screening; - . presence of covid-19 pneumonia, with a typical, indeterminate or atypical compatible image in a chest tomography exam (see definition below) - - presence of one of the following criteria: - need for> 3l of o2 in the catheter / mask or> 25% in the venturi mask to maintain o2 saturation> 92% b presence of respiratory distress syndrome with pao2 / fio2 <300mmhg if intubated, within 48 hours of orotracheal intubation - absence of a history of serious adverse reactions to transfusion, for example, anaphylaxis; - .participation approval by the research clinician