Outcome name:The proportion of subjects per arm requiring artificial ventilation (intubation and mechanical ventilation [MV]; extracorporeal membrane oxygenation [ECMO]; heated; humidified high-flow nasal cannula oxygen [HFNC]; noninvasive positive pressure ventilation [NiPPV]) or death from Day 1 through Day 29 of study treatment.Measure:DLTs will be used to establish the RP2D.Timepoints:Part 1 and Part 2

Outcome name:The proportion of subjects per arm requiring artificial ventilation (intubation and mechanical ventilation [MV]; extracorporeal membrane oxygenation [ECMO]; heated; humidified high-flow nasal cannula oxygen [HFNC]; noninvasive positive pressure ventilation [NiPPV]) or death from Day 1 through Day 29 of study treatment.Measure:DLTs will be used to establish the RP2D.Timepoints:Part 1 and Part 2