inclusion criteria: - at least 18 years old - confirmed sars-cov-2 viral infection - advanced covid-19 with score of 3 or 4 on niaid scale (first 40 patients) or score of 3 on niaid scale (last 40 patient - has at least one of the following: fever, cough, sore throat, malaise, headache, muscle pain, shortness of breath, confusion or severe lower respiratory symptoms - off antiviral medications at least 24 hours prior to first dose of study drug (except for remdesivir) - able to provide consent - agree to appropriate methods of contraception

inclusion criteria: - at least 18 years old - confirmed sars-cov-2 viral infection - advanced covid-19 with score of 3 or 4 on niaid scale (first 40 patients) or score of 3 on niaid scale (last 40 patient - has at least one of the following: fever, cough, sore throat, malaise, headache, muscle pain, shortness of breath, confusion or severe lower respiratory symptoms - off antiviral medications at least 24 hours prior to first dose of study drug (except for remdesivir) - able to provide consent - agree to appropriate methods of contraception