inclusion criteria (all required): positive sars-cov-2 diagnostic (on pharyngeal swab of deep airways material) severe pneumonia defined by the presence of at least one of the following criteria: respiratory rate ≥25 breaths /min arterial oxygen saturation≤93% at rest on ambient air pao2/fio2 ≤300 mmhg coagulopathy, defined by the presence of at least one of the following criteria: d-dimer >4 times the upper level of normal reference range sepsis-induced coagulopathy (sic) score >4 no need for invasive mechanical ventilation

inclusion criteria (all required): positive sars-cov-2 diagnostic (on pharyngeal swab of deep airways material) severe pneumonia defined by the presence of at least one of the following criteria: respiratory rate ≥25 breaths /min arterial oxygen saturation≤93% at rest on ambient air pao2/fio2 ≤300 mmhg coagulopathy, defined by the presence of at least one of the following criteria: d-dimer >4 times the upper level of normal reference range sepsis-induced coagulopathy (sic) score >4 no need for invasive mechanical ventilation

inclusion criteria (all required): - positive sars-cov-2 diagnostic (on pharyngeal swab of deep airways material) - severe pneumonia defined by the presence of at least one of the following criteria: 1. respiratory rate ≥25 breaths /min 2. arterial oxygen saturation≤93% at rest on ambient air 3. pao2/fio2 ≤300 mmhg - coagulopathy, defined by the presence of at least one of the following criteria: 1. d-dimer >4 times the upper level of normal reference range 2. sepsis-induced coagulopathy (sic) score >4 - no need for invasive mechanical ventilation

inclusion criteria (all required): - positive sars-cov-2 diagnostic (on pharyngeal swab of deep airways material) - severe pneumonia defined by the presence of at least one of the following criteria: 1. respiratory rate ≥25 breaths /min 2. arterial oxygen saturation≤93% at rest on ambient air 3. pao2/fio2 ≤300 mmhg - coagulopathy, defined by the presence of at least one of the following criteria: 1. d-dimer >4 times the upper level of normal reference range 2. sepsis-induced coagulopathy (sic) score >4 - no need for invasive mechanical ventilation