- allergy to ivermectin or doxycycline; or other contraindications to any of the study medications - history of chronic heart disease (ihd, heart failure, documented cardiomyopathy etc) - history of chronic liver disease (sgpt value more than 3 times of normal value) - history of chronic kidney disease (s. creatinine for male >1.3 mg/dl or >115 µmol/l and for female >1.2 mg/dl or >106.1 µmol/l) - pregnant or lactating women - participated in any other clinical trial within last 4 weeks - h/o received ivermectin/doxycycline within last 7 days

- allergy to ivermectin or doxycycline; or other contraindications to any of the study medications - history of chronic heart disease (ihd, heart failure, documented cardiomyopathy etc) - history of chronic liver disease (sgpt value more than 3 times of normal value) - history of chronic kidney disease (s. creatinine for male >1.3 mg/dl or >115 µmol/l and for female >1.2 mg/dl or >106.1 µmol/l) - pregnant or lactating women - participated in any other clinical trial within last 4 weeks - h/o received ivermectin/doxycycline within last 7 days