- objectively documented deep vein thrombosis or pulmonary embolism - patients in whom there is very high suspicion for pulmonary embolism and are on full-dose anticoagulation as per the treating physician - platelets <30,000 not due to disseminated intravascular coagulation (dic), based on the international society of thrombosis and haemostasis (isth) criteria and american society of hematology (ash) frequently asked questions - active bleeding that poses a contraindication to therapeutic anticoagulation in the opinion of the investigator. - history of bleeding diathesis (e.g., hemophilia, severe von willebrand disease, severe thrombocytopathy) - history of intracranial hemorrhage in the last 90 days - history of ischemic stroke in the past 2 weeks - major neurosurgical procedure in the past 30 days - cardiothoracic surgery in the past 30 days - intra-abdominal surgery in the past 30 days - intracranial malignancy - patients who require therapeutic anticoagulation for other reasons like atrial fibrillation, deep venous thrombosis, pulmonary embolism, or antiphospholipid syndrome.

- objectively documented deep vein thrombosis or pulmonary embolism - patients in whom there is very high suspicion for pulmonary embolism and are on full-dose anticoagulation as per the treating physician - platelets <30,000 not due to disseminated intravascular coagulation (dic), based on the international society of thrombosis and haemostasis (isth) criteria and american society of hematology (ash) frequently asked questions - active bleeding that poses a contraindication to therapeutic anticoagulation in the opinion of the investigator. - history of bleeding diathesis (e.g., hemophilia, severe von willebrand disease, severe thrombocytopathy) - history of intracranial hemorrhage in the last 90 days - history of ischemic stroke in the past 2 weeks - major neurosurgical procedure in the past 30 days - cardiothoracic surgery in the past 30 days - intra-abdominal surgery in the past 30 days - intracranial malignancy - patients who require therapeutic anticoagulation for other reasons like atrial fibrillation, deep venous thrombosis, pulmonary embolism, or antiphospholipid syndrome.