inclusion criteria: - adults 18 to 70 years of age. - serious or critically ill patients confirmed for sars-cov-2 disease (rt-pcr). - meet the criteria for disease with sars-cov-2 disease, phase ii (moderate) and phase iii (severe) . - suspected cytokine release syndrome with hscore 169 points. - presence of severe acute hypoxemia with spo2 <90% in ambient air and / or pao2 / fio2 <300 mmhg. - meet criteria (plain chest tomography or plain chest radiograph) for sars-cov-2 disease. - supplemental oxygen requirement either through the facial store plus reservoir bag, high-flow nasal tips or advanced airway management and invasive mechanical ventilation support.

inclusion criteria: - adults 18 to 70 years of age. - serious or critically ill patients confirmed for sars-cov-2 disease (rt-pcr). - meet the criteria for disease with sars-cov-2 disease, phase ii (moderate) and phase iii (severe) . - suspected cytokine release syndrome with hscore 169 points. - presence of severe acute hypoxemia with spo2 <90% in ambient air and / or pao2 / fio2 <300 mmhg. - meet criteria (plain chest tomography or plain chest radiograph) for sars-cov-2 disease. - supplemental oxygen requirement either through the facial store plus reservoir bag, high-flow nasal tips or advanced airway management and invasive mechanical ventilation support.