- patient has no interest in participating in the trial. - bilateral pulmonary infiltrate related to heart failure or other cause of water overload. - virus positive respiratory viral panel other than covid-19 - history of allergy to plasma, sodium citrate, or methylene blue. - patients with a history of autoimmune diseases or selective iga insufficiency. - those patients who are participating in other protocols.

- patient has no interest in participating in the trial. - bilateral pulmonary infiltrate related to heart failure or other cause of water overload. - virus positive respiratory viral panel other than covid-19 - history of allergy to plasma, sodium citrate, or methylene blue. - patients with a history of autoimmune diseases or selective iga insufficiency. - those patients who are participating in other protocols.