- pregnancy and breastfeeding - hypersensitivity to colchicine - hypersensitivity to ruxolitinib - hypersensitivity to secukinumab - known liver failure - glomerular filtration rate <20 ml/ min - physician judgment that the patient will need mechanical ventilation in 24 hours - qtc > 450 ms - other indications for to colchicine, ruxolitinib, and secukinumab - chronic therapy with corticosteroids or immunosuppressive therapy - active cancer

- pregnancy and breastfeeding - hypersensitivity to colchicine - hypersensitivity to ruxolitinib - hypersensitivity to secukinumab - known liver failure - glomerular filtration rate <20 ml/ min - physician judgment that the patient will need mechanical ventilation in 24 hours - qtc > 450 ms - other indications for to colchicine, ruxolitinib, and secukinumab - chronic therapy with corticosteroids or immunosuppressive therapy - active cancer